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Benzalkonium Chloride  ( Anti-bacterials, Topical.... )
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Mode Of Action

The greatest biocidal activity is associated with the C12-C14 alkyl derivatives. The mechanism of bactericidal/microbicidal action is thought to be due to disruption of intermolecular interactions. This can cause dissociation of cellular membrane lipid bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. Enzymes, which finely control a wide range of respiratory and metabolic cellular activities, are particularly susceptible to deactivation. Critical intermolecular interactions and tertiary structures in such highly specific biochemical systems can be readily disrupted by cationic surfactants.
Benzalkonium chloride solutions are rapidly acting biocidal agents with a moderately long duration of action. They are active against bacteria and some viruses, fungi, and protozoa. Bacterial spores are considered to be resistant. Solutions are bacteriostatic or bactericidal according to their concentration. Gram-positive bacteria are generally more susceptible than Gram-negative. Activity is not greatly affected by pH, but increases substantially at higher temperatures and prolonged exposure times.

Pharmacokinetics

Updating..................

Indications

Treating minor cuts, scrapes, and burns.

Contraindications

You should not use products that contain benzalkonium chloride lotion if you have had previous adverse effects from using the chemical Benzalkonium.

Side Effects

Minor irritation at the application site.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection; severe or persistent irritation, redness, pain, or swelling.

Drug Interactions

Some MEDICINES MAY INTERACT with Benzalkonium Chloride Solution. However, no specific interactions are known at this time.

Precautions

Some medical conditions may interact with Benzalkonium Chloride Solution. Care should be taken if any of the following apply:
Pregnant, planning to become pregnant, or are breast-feeding.
Taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
Allergies to medicines, foods, or other substances.

Usage in Pregnancy & Lactation

Care should be taken during pregnancy and breast feeding.

Dosage & Administration

Adult Dosage (>12 years):
0.010 % As recommended Ophthalmic drops As required.
0.100 to 0.200 % As recommended Topical As Required.
Paedriatic Dosage (20 Kg):
0.150 % As recommended Topical As Required.
Neonatal Dosage (3 Kg):
0.150 % As recommended Topical As Required

Brands Available in Pakistan
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